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My BP is stable and I`m doing really well on this medicine.
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Two systems of nomenclature are used in reference to angiotensin-II receptor antagonists: one system employs Roman numerals, and the other is based on the amino acids that make up the A-I and A-II receptors (AT 1 receptor and AT 2 receptor).
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Neither losartan nor its principal active metabolite exhibits any partial agonist activity at the AT 1 receptor, and both have much greater affinity (about 1000-fold) for the AT 1 receptor than for the AT 2 receptor.
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The terminal half-life of Losartan is about 2 hours and of the metabolite is about 6 to 9 hours.
Discontinuations of Losartan because of side effects were similar to placebo (19% for Losartan, 24% for placebo).
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Prematurity, intrauterine growth retardation, and patent ductus arteriosus have also been reported, although it is not clear whether these occurrences were due to exposure to the drug.
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